Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Nkx2-5  NK2 homeobox 5   (Synonyms: Csx, Nkx-2.5, Nkx2.5, tinman)
Results	Reference
1*	J:231312 Baardman ME, Zwier MV, Wisse LJ, Gittenberger-de Groot AC, Kerstjens-Frederikse WS, Hofstra RM, Jurdzinski A, Hierck BP, Jongbloed MR, Berger RM, Plosch T, DeRuiter MC, Common arterial trunk and ventricular non-compaction in Lrp2 knockout mice indicate a crucial role of LRP2 in cardiac development. Dis Model Mech. 2016 Apr 1;9(4):413-25
1*	J:162870 Bax NA, Bleyl SB, Gallini R, Wisse LJ, Hunter J, Van Oorschot AA, Mahtab EA, Lie-Venema H, Goumans MJ, Betsholtz C, Gittenberger-de Groot AC, Cardiac malformations in Pdgfralpha mutant embryos are associated with increased expression of WT1 and Nkx2.5 in the second heart field. Dev Dyn. 2010 Aug;239(8):2307-17
1	J:196959 Castagnaro L, Lenti E, Maruzzelli S, Spinardi L, Migliori E, Farinello D, Sitia G, Harrelson Z, Evans SM, Guidotti LG, Harvey RP, Brendolan A, Nkx2-5(+)islet1(+) mesenchymal precursors generate distinct spleen stromal cell subsets and participate in restoring stromal network integrity. Immunity. 2013 Apr 18;38(4):782-91
1	J:175381 Espinoza-Lewis RA, Liu H, Sun C, Chen C, Jiao K, Chen Y, Ectopic expression of Nkx2.5 suppresses the formation of the sinoatrial node in mice. Dev Biol. 2011 Aug 15;356(2):359-69
1*	J:122248 Gittenberger-de Groot AC, Mahtab EA, Hahurij ND, Wisse LJ, Deruiter MC, Wijffels MC, Poelmann RE, Nkx2.5-negative myocardium of the posterior heart field and its correlation with podoplanin expression in cells from the developing cardiac pacemaking and conduction system. Anat Rec (Hoboken). 2007 Jan;290(1):115-22
1	J:173586 Hahurij ND, Kolditz DP, Bokenkamp R, Markwald RR, Schalij MJ, Poelmann RE, Gittenberger-DE Groot AC, Blom NA, Accessory atrioventricular myocardial pathways in mouse heart development: substrate for supraventricular tachycardias. Pediatr Res. 2011 Jul;70(1):37-43
1	J:223458 He L, Tian X, Zhang H, Hu T, Huang X, Zhang L, Wang Z, Zhou B, BAF200 is required for heart morphogenesis and coronary artery development. PLoS One. 2014;9(10):e109493
1	J:177490 Jongbloed MR, Vicente-Steijn R, Douglas YL, Wisse LJ, Mori K, Yokota Y, Bartelings MM, Schalij MJ, Mahtab EA, Poelmann RE, Gittenberger-De Groot AC, Expression of Id2 in the second heart field and cardiac defects in Id2 knock-out mice. Dev Dyn. 2011 Nov;240(11):2561-77
1	J:294789 Kasahara H, Bartunkova S, Schinke M, Tanaka M, Izumo S, Cardiac and extracardiac expression of Csx/Nkx2.5 homeodomain protein. Circ Res. 1998 May 18;82(9):936-46
1	J:152142 Koshiba-Takeuchi K, Mori AD, Kaynak BL, Cebra-Thomas J, Sukonnik T, Georges RO, Latham S, Beck L, Henkelman RM, Black BL, Olson EN, Wade J, Takeuchi JK, Nemer M, Gilbert SF, Bruneau BG, Reptilian heart development and the molecular basis of cardiac chamber evolution. Nature. 2009 Sep 3;461(7260):95-8
1	J:293668 Li H, Li D, Wang Y, Huang Z, Xu J, Yang T, Wang L, Tang Q, Cai CL, Huang H, Zhang Y, Chen Y, Nkx2-5 defines a subpopulation of pacemaker cells and is essential for the physiological function of the sinoatrial node in mice. Development. 2019 Jul 25;146(14):dev178145
1	J:251798 Lin X, Zhao W, Jia J, Lin T, Xiao G, Wang S, Lin X, Liu Y, Chen L, Qin Y, Li J, Zhang T, Hao W, Chen B, Xie R, Cheng Y, Xu K, Yao K, Huang W, Xiao D, Sun Y, Ectopic expression of Cripto-1 in transgenic mouse embryos causes hemorrhages, fatal cardiac defects and embryonic lethality. Sci Rep. 2016 Sep 30;6:34501
1	J:220807 Shamis Y, Cullen DE, Liu L, Yang G, Ng SF, Xiao L, Bell FT, Ray C, Takikawa S, Moskowitz IP, Cai CL, Yang X, Li X, Maternal and zygotic Zfp57 modulate NOTCH signaling in cardiac development. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):E2020-9
1	J:239700 Shekhar A, Lin X, Liu FY, Zhang J, Mo H, Bastarache L, Denny JC, Cox NJ, Delmar M, Roden DM, Fishman GI, Park DS, Transcription factor ETV1 is essential for rapid conduction in the heart. J Clin Invest. 2016 Dec 01;126(12):4444-4459
1	J:156167 Sun Y, Liang X, Najafi N, Cass M, Lin L, Cai CL, Chen J, Evans SM, Islet 1 is expressed in distinct cardiovascular lineages, including pacemaker and coronary vascular cells. Dev Biol. 2007 Apr 1;304(1):286-96
1	J:334587 Wang L, Lin L, Qi H, Chen J, Grossfeld P, Endothelial Loss of ETS1 Impairs Coronary Vascular Development and Leads to Ventricular Non-Compaction. Circ Res. 2022 Aug 19;131(5):371-387
1	J:326525 Wu T, Liang Z, Zhang Z, Liu C, Zhang L, Gu Y, Peterson KL, Evans SM, Fu XD, Chen J, PRDM16 Is a Compact Myocardium-Enriched Transcription Factor Required to Maintain Compact Myocardial Cardiomyocyte Identity in Left Ventricle. Circulation. 2022 Feb 22;145(8):586-602
1	J:283053 Xu J, Wang L, Li H, Yang T, Zhang Y, Hu T, Huang Z, Chen Y, Shox2 regulates osteogenic differentiation and pattern formation during hard palate development in mice. J Biol Chem. 2019 Nov 29;294(48):18294-18305